Where exactly should tretinoin cream be used on the face?Tretinoin cream should be applied to clean, completely dry skin, usually at night. Take a pea-sized amount and spread a thin layer over the areas you want to treat. This usually includes the forehead, cheeks, chin, and nose. Avoid applying tretinoin too close to sensitive areas like the eyes, lips, and the corners of the nose, as these spots get irritated more easily. It’s best to wait around 15–20 minutes after washing your face before a ?